Clinical Studies

ANMERKUNG: In diesen Studien wurden die Produkte Prolact+ H2MF® und Prolact CR® verwendet. Die Zusammensetzung von Prolact+ H2MF® und HumavantTM HMF ist identisch. Die Zusammensetzung von Prolact CR® und HumavantTM CR ist identisch. In Nordamerika werden die Produkte unter den Namen Prolact+ H2MF® und Prolact CR® vertrieben, außerhalb Nordamerikas unter den Namen HumavantTM HMF und HumavantTM CR.



Reduktion der Versorgungskosten

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less 1500 g birth weight.ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

 

Ganapathy V, et al. “Costs of Necrotizing Enterocolitis and Cost-Effectiveness of Exclusively Human Milk-Based Products in Feeding Extremely Premature Infants.” Breastfeeding Medicine. February 2012. 7(1):29-37. doi: 10.1089/bfm.2011.0002.

 

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Weniger NEK-Fälle (nekrotisierende Enterokolitis)

 

Huston RK, et al. "Improving Growth for Infants ≤1250 Grams Receiving an Exclusive Human Milk Diet." Nutrients. February 2018.  doi: 10.1002/ncp.10054.

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

Hermann K, et al. “An Exclusively Human Milk Diet Reduces Necrotizing Enterocolitis.” Breastfeeding Medicine. May 2014.  9(4): 184–190. doi: 10.1089/bfm.2013.0121

Cristofalo EA, et al. “Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants.” The Journal of Pediatrics. December 2013. 163 (6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

Huston RK, et al. "Decreasing Necrotizing Enterocolitis and Gastrointestinal Bleeding in the Neonatal Intensive Care Unit: The Role of Donor Human Milk and Exclusive Human Milk Diet in Infants Less <= to 1500 g birth weight.ICAN: Adult Child and Adolescent Nutrition. 20 August 2013. 13:127. doi: 10.1186/1471-2431-13-127

 

Sullivan S, et al. “An exclusively human milk-based diet is associated with a lower rate of necrotizing enterocolitis than a diet of human milk and bovine milk-based products.” The Journal of Pediatrics 2010. doi: 10.1016/j.jpeds.2009.10.040.
 

Wachstum


Visuthranukul C, Abrams SA, Hawthorne KM, et al. Premature small for gestational age infants fed an exclusive human milk-based diet achieve catch-up growth without metabolic consequences at 2 years of age." Archives of Disease in Childhood - Fetal and Neonatal Edition Published Online First: 13 November 2018. doi: 10.1136/archdischild-2017-314547

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. 
Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Huston RK, et al. 
"Improving Growth for Infants ≤1250 Grams Receiving an Exclusive Human Milk Diet." Nutrients. February 2018.   doi : 10.1002/ncp.10054.

Hair A, et al. "
Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74.  doi :10.1089/bfm.2015.0134.

 
Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459


Reduktion der totalen parenteralen Ernährung

Hair AB, et al."Beyond Necrotizing Enterocolitis: Other Clinical Advantages of an Exclusive Human Milk Diet." Breastfeeding Medicine.http://doi.org/10.1089/bfm.2017.0192
 

Cristofalo EA, et al. “Randomized Trial of Exclusive Human Milk versus Preterm Formula Diets in Extremely Premature Infants.” The Journal of Pediatrics. December 2013. 163(6):1592-1595. doi: 10.1016/j.jpeds.2013.07.011

 

Ghandehari H, et al.“An Exclusive Human Milk-Based Diet in Extremely Premature Infants Reduces the Probability of Remaining on Total Parenteral Nutrition: A reanalysis of the data.”  BMC Pediatrics. 2012. 5: 188. doi:10.1186/1756-0500-5-188.

 


Flexibilität bei der Ernährung

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Guidelines for Acute Care of the Neonate (24th Edition). Texas Children/Baylor College. 2016.

 

Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.”  Breastfeeding Medicine. June 2014. 9(6): 281-0285. doi:10.1089/bfm.2014.0024.

 

Hair A, et al. "Human milk feeding supports adequate growth in infants < 1250 grams birth weight." BMC Research Notes. 13 November 2013. doi: 10.1186/1756-0500-6-459

 

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk. Nutrients. 11 February 2015. 7(2): 1174-1183. doi:10.3390/nu7021174.

 


Spätsepsis

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 


Frühgeborenen-Retinopathie (ROP)

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 


Ernährungsintoleranz

Sandhu A, Fast S, Bonnar K, Baier RJ, Narvey M. Human-Based Human Milk Fortifier as Rescue Therapy in Very Low Birth Weight Infants Demonstrating Intolerance to Bovine-Based Human Milk FortifierBreastfeed Med. 2017;12(9):570–573. doi:10.1089/bfm.2017.0017

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 


Mortalität

Assad M, et al. "Decreased cost and improved feeding tolerance in VLBW infants fed an exclusive human milk diet."  Journal of Perinatology. 12 November 2015. doi: 10.1038/jp.2015.168.

 

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 
Abrams SA, et al. “Greater mortality and morbidity in extremely preterm infants fed a diet containing cow milk protein products.”  Breastfeeding Medicine. June 2014. 9(6): 281-0285. doi:10.1089/bfm.2014.0024.


Beatmungstage

Hair A, et al. "Beyond Necrotizing Enterocolitis Prevention: Improving Outcomes with an Exclusive Human Milk–Based Diet."  Breastfeeding Medicine. March 2016. 11(2): 70-74. doi:10.1089/bfm.2015.0134.

 


Kürzere Aufenthalte auf der neonatologischen Intensivstation

Hair A, et al. "Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner  Breastfeeding Medicine. April 2016. doi:10.1089/bfm.2015.0166.


Klinische Studien zu HumavantTM CR

Hair A, et al. "Premature Infants 750–1,250 g Birth Weight Supplemented with a Novel Human Milk-Derived Cream Are Discharged Sooner  Breastfeeding Medicine. April 2016. doi:10.1089/bfm.2015.0166.
 

Tabata M, et al. "Fortifier and Cream Improve Fat Delivery in Continuous Enteral Infant Feeding of Breast Milk  Nutrients February 2015. doi:10.3390/nu7021174.


Hair A, et al. "Randomized Trial of Human Milk Cream as a Supplement to Standard Fortification of an Exclusive Human Milk-Based Diet in Infants 750-1250 g Birth Weight  J. Peds November 2014.